list_a = [] list_b=[] with open("chean.txt","r") as a: for line in a.readlines(): screen_a = line.strip() if screen_a not in list_a and screen_a !="": list_a.append(screen_a) with open("screen_lot.txt","r") as b: for line in b.readlines(): screen_b = line.strip().split(",")[1] if screen_b not in list_b and screen_b !="": list_b.append(screen_b) print(len(list_a),list_a) print(len(list_b),list_b) list_c = list(set(list_b).difference(set(list_a))) list_c.sort() print(len(list_c),list_c)